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Editorially curated · qa-return-clinically-actionable-results
Return of Clinically Actionable Genomic Research Findings
Program identifies medically actionable variants in research genomes, confirms them clinically, returns consented findings, and connects participants and relatives with surveillance and preventive care.
01 / Project overview
What the record establishes.
- Geographic scope
- National QPHI participant cohort with HMC referral
- Project type
- translational return-of-results program
- Research domain
- clinical genomics, hereditary disease, and preventive care
- Years
- 2025–
- Lifecycle status
- active and expanding
- Status basis
- QPHI's current page states that it has implemented a clinical referral pathway after a BRCA pilot and is expanding to a broader gene/condition panel.
- Status evidence date
- 2026-08-15
- Scale
- 14,392 whole genomes analyzed, approximately 3.5% carrying clinically actionable variants. The published BRCA pilot screened 6,142 genomes, confirmed 10 carriers, enrolled eight in surveillance, and extended testing to 20 relatives.
02 / Organizations and population
Who and what the project connects.
- Lead organizations
- Qatar Precision Health Institute
- Partner organizations
- Hamad Medical Corporation Cancer Genetics Program
- Organism / population
- QPHI/Qatar Biobank participants with actionable germline variants and their relatives
03 / Data and access
What exists and how it can be reached.
Data types
- whole-genome sequencing
- actionable variant curation
- clinical confirmation
- return of results
- cascade testing
Data access
Individual results returned under consent; research genomes remain controlled.
Identifiers
No public accession or identifier is listed for this record.
04 / Evidence and provenance
Why the record is included.
Inclusion basis
Large, genome-wide translational program with a documented clinical pathway and quantitative pilot.
Editorial note
Direct downstream use of QGP/QPHI genomes; not a new population cohort.
Sources
- primary record source Verified 2026-08-15
- additional record source Verified 2026-08-15
Release v0.2.0