Nuqta Genomics
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Editorially curated · gcc-uae-arab-pangenome

UAE-Based Arab Pangenome Reference

Saudi ArabiaUnited Arab EmiratesOmanHuman health and population genomicsCompleted / retained

Built 106 haplotype-resolved assemblies and nuclear and mitochondrial pangenomes from PacBio HiFi, Oxford Nanopore ultralong and Hi-C data.

01 / Project overview

What the record establishes.

Geographic scope
UAE-based cohort with participants originating from UAE, Saudi Arabia, Oman and five non-GCC Arab countries
Project type
Regional pangenome reference
Research domain
Human pangenomics and genomic medicine
Years
Not stated
Lifecycle status
completed
Status basis
The reference, public files, code and primary paper were released in 2025.
Status evidence date
2025-07-24
Scale
53 participants; 111.96 Mb of sequence absent from existing references, 8.94 million population-specific small variants and 235,195 structural variants reported.

02 / Organizations and population

Who and what the project connects.

Lead organizations
Mohammed Bin Rashid University of Medicine and Health Sciences · Dubai Health · Dubai Health Center for Applied and Translational Genomics
Partner organizations
Not stated
Organism / population
53 healthy Arab residents of the UAE, including 50 unrelated adults and one trio

03 / Data and access

What exists and how it can be reached.

Data types

  • PacBio HiFi
  • Oxford Nanopore ultralong reads
  • Hi-C
  • de novo assemblies
  • pangenome graphs
  • VCF
  • PacBio HiFi sequencing
  • Oxford Nanopore ultralong sequencing
  • phased assemblies
  • pangenome graph
  • small and structural variants

Data access

Open assemblies, pangenome files, VCF and code; raw reads in SRA

Identifiers

  • BioProjectPRJNA1108179
  • Sequence studySRP509490
  • BioProject rangePRJNA1151091-PRJNA1151118
  • BioProject rangePRJNA1152014-PRJNA1152091
  • PubMedPMID:40707445
  • DOIDOI:10.1038/s41467-025-61645-w
  • DOI10.5281/zenodo.13755057

04 / Evidence and provenance

Why the record is included.

Inclusion basis

Open regional reference with multi-GCC participants, durable repository accessions and reproducible code.

Editorial note

UAE-led; likely duplicated in the UAE country inventory and should be merged by DOI/accession. Not the same as the Emirati-only T2T pangenome or the Emirati Reference Genome Platform. All participants resided in the UAE but represented UAE, Saudi, Omani, Jordanian, Egyptian, Moroccan, Syrian, and Yemeni backgrounds.

Sources

  1. primary record source Verified 2026-08-15
  2. additional record source Verified 2026-08-15
  3. additional record source Verified 2026-08-15
  4. additional record source Verified 2026-08-15
  5. additional record source Verified 2026-08-15
  6. additional record source Verified 2026-08-15
  7. additional record source Verified 2026-08-15
  8. additional record source Verified 2026-08-15

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