Editorially curated · qa-qbri-qgp-autism-wgs
QBRI-Qatar Genome Autism Whole-Genome Sequencing Initiative
A QBRI-QGP family sequencing initiative designed to identify rare and inherited autism-risk variants in Qataris and translate locally relevant genomic findings into screening and counseling knowledge.
01 / Project overview
What the record establishes.
- Geographic scope
- Qatari families recruited primarily through the Shafallah Center in Doha
- Project type
- family-trio disease genomics cohort
- Research domain
- autism genomics and neurodevelopmental precision medicine
- Years
- 2019–2024
- Lifecycle status
- planned sequencing phase and initial cohort analysis completed
- Status basis
- The October 2019 agreement specified two years of whole-genome sequencing; a 150-person trio cohort recruited under the program was published on 27 October 2024.
- Status evidence date
- 2024-10-27
- Scale
- Published analysis included 50 autism probands and both biological parents, totaling 150 genomes at approximately 35x mean depth; it reported 37 candidate variants and 13 genes not previously linked to autism.
02 / Organizations and population
Who and what the project connects.
- Lead organizations
- Qatar Biomedical Research Institute · Qatar Genome Programme
- Partner organizations
- Hamad Bin Khalifa University · Shafallah Center for Persons with Disabilities · Qatar Foundation
- Organism / population
- Qataris with autism spectrum disorder and their apparently unaffected biological parents
03 / Data and access
What exists and how it can be reached.
Data types
- family-trio whole-genome sequencing
- clinical autism assessments
- SNV and indel analysis
- repeat-expansion analysis
- consanguinity and pedigree data
Data access
Participant-level genomes are not documented as openly deposited; access is subject to QBRI/Qatar ethics, consent and data-governance restrictions.
Identifiers
- Other
QBRI-2010-002
04 / Evidence and provenance
Why the record is included.
Inclusion basis
Named national institutional collaboration with a reusable family-trio cohort and a published multi-genome dataset.
Editorial note
Distinct from Sidra's BARAKA-Qatar program in lead institution, recruitment pathway and published cohort description, although participant overlap cannot be excluded from public sources. The 2024 publication establishes an analyzed phase, not necessarily closure of all QBRI autism genomics work.
Sources
- primary record source Verified 2026-08-15
- additional record source Verified 2026-08-15
- additional record source Verified 2026-08-15
- additional record source Verified 2026-08-15
Release v0.2.0