Repository series · ncbi-prjna167360
Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia
Whole transcript expression was profiled using the Affymetrix 1.0 array in human bronchial epithelial cells exposed to PM collected from Saudi Arabia for 1 or 4 days. The differentially expressed genes were identified and analyzed for enriched networks and pathways using Ingenuity Pathway Analysis (IPA). We have identified 140 and 230 genes that significantly changed more than 1.5 fold after PM exposure for 1 or 4 days, respectively. IPA analysis revealed that different exposure durations triggered distinct pathways. Genes involved in NRF2-mediated response to oxidative stress were up-regulated after 1 day exposure. In contrast, cells exposed for 4 days exhibited significantly changes in genes related to cholesterol and lipid synthesis pathways. Overall design: We analyzed gene expression profiles from 12 samples collected at two different time points, including 2 untreated controls, 2 normal PM treated samples and 2 storm PM treated samples for each time point.
The accession and its GCC connection are verified. Registration alone does not establish that the broader research programme remains active.
01 / Project overview
What the record establishes.
- Geographic scope
- Saudi Arabia connection indexed in BioProject metadata
- Project type
- Repository project
- Research domain
- Human health and population genomics
- Years
- 2012–
- Lifecycle status
- repository_recorded
- Status basis
- Registered in NCBI BioProject on 2012/08/01; operational lifecycle is not asserted.
- Status evidence date
- 2012-08-01
- Scale
- 1 BioProject accession grouped by matching submitter, date, data type and narrative.
02 / Organizations and population
Who and what the project connects.
- Lead organizations
- Environmental Medicine, NYU School of Medicine
- Partner organizations
- Not stated
- Organism / population
- Homo sapiens
03 / Data and access
What exists and how it can be reached.
Data types
- Transcriptome or Gene expression
- Array
- Transcriptome
Data access
Public repository metadata with linked data where supplied by the submitter
Identifiers
- BioProject
PRJNA167360
04 / Evidence and provenance
Why the record is included.
Inclusion basis
Exact country-name match in authoritative NCBI BioProject metadata; repeated submissions are grouped into one Atlas series.
Editorial note
Repository verification confirms the accession and regional connection, not whether the broader research programme remains active.
Sources
- primary record source Verified 2026-08-15
Release v0.2.0