Repository series · ncbi-prjna1359592
High Prevalence of Homozygous BRCA1/2 Mutations Reveals Aggressive Prostate Cancer in UAE and Arab Patients
Prostate cancer (PCa) is a leading malignancy among men globally and is increasingly prevalent in the United Arab Emirates (UAE), where it ranks as the second most common cancer in males. While BRCA1 and BRCA2 genes are well-established contributors to breast and ovarian cancer, their role in PCa, particularly within Arab populations, remains poorly understood. This study aims to characterize the mutational landscape of BRCA1 and BRCA2 genes in PCa among UAE and Arab patients, with a specific focus on the prevalence and clinical significance of homozygous mutations in high-grade tumors.
The accession and its GCC connection are verified. Registration alone does not establish that the broader research programme remains active.
01 / Project overview
What the record establishes.
- Geographic scope
- United Arab Emirates connection indexed in BioProject metadata
- Project type
- Repository project
- Research domain
- Human health and population genomics
- Years
- 2025–
- Lifecycle status
- repository_recorded
- Status basis
- Registered in NCBI BioProject on 2025/11/12; operational lifecycle is not asserted.
- Status evidence date
- 2025-11-12
- Scale
- 1 BioProject accession grouped by matching submitter, date, data type and narrative.
02 / Organizations and population
Who and what the project connects.
- Lead organizations
- University of Sharjah
- Partner organizations
- Not stated
- Organism / population
- Not stated
03 / Data and access
What exists and how it can be reached.
Data types
- Raw sequence reads
- Sequencing
- Genome
Data access
Public repository metadata with linked data where supplied by the submitter
Identifiers
- BioProject
PRJNA1359592
04 / Evidence and provenance
Why the record is included.
Inclusion basis
Exact country-name match in authoritative NCBI BioProject metadata; repeated submissions are grouped into one Atlas series.
Editorial note
Repository verification confirms the accession and regional connection, not whether the broader research programme remains active.
Sources
- primary record source Verified 2026-08-15
Release v0.2.0