Repository series · ncbi-prjeb36683
A fatal outbreak of hypervirulent and multidrug resistant clone (ST2096) of Klebsiella pneumoniae silently transmitting in a Saudi Arabia western region hospital: a clinical…
Repository title: A fatal outbreak of hypervirulent and multidrug resistant clone (ST2096) of Klebsiella pneumoniae silently transmitting in a Saudi Arabia western region hospital: a clinical and molecular surveillance study
We identified an ongoing clonal transmission of hypervirulent MDR ST2096 K. pneumoniae strain of the cc14 followed by the global high-risk clone ST14 of the same clonal group. ST2096 transmitted silently within the hospital and was found to be associated with high mortality (58.6%). The transmission of ST2096 predominated over other sequence types until the end of our collection period on March 2018. We identified the outbreak index case arriving to the hospital on December 2016. The index case carried a hypervirulent and highly resistant K. pneumoniae ST2096 isolate had been transferred between several wards for treatments and clinical-related tests. Consequently, the transmission network model illustrated the spread of ST2096 from the ward A to the intensive care unit (ICU) and other wards that hosts long-term care patients within the hospital. The transmission network analysis and the genetic distance between isolates suggested the involvement of other unsampled isolates that could have been colonizing hospital staff or contaminating within the hospital environmental. Furthermore, the identified outbreak wards were found to be directly linked to shortage and rotation of health-care staff, antibiotic usage and patient interaction and length of stay.
The accession and its GCC connection are verified. Registration alone does not establish that the broader research programme remains active.
01 / Project overview
What the record establishes.
- Geographic scope
- Saudi Arabia connection indexed in BioProject metadata
- Project type
- Repository project
- Research domain
- Pathogen genomics and infectious disease
- Years
- 2020–
- Lifecycle status
- repository_recorded
- Status basis
- Registered in NCBI BioProject on 2020/02/11; operational lifecycle is not asserted.
- Status evidence date
- 2020-02-11
- Scale
- 1 BioProject accession grouped by matching submitter, date, data type and narrative.
02 / Organizations and population
Who and what the project connects.
- Lead organizations
- King Abdullah University of Science and Technology
- Partner organizations
- Not stated
- Organism / population
- Not stated
03 / Data and access
What exists and how it can be reached.
Data types
- Other
- Sequencing
- Genome
Data access
Public repository metadata with linked data where supplied by the submitter
Identifiers
- BioProject
PRJEB36683
04 / Evidence and provenance
Why the record is included.
Inclusion basis
Exact country-name match in authoritative NCBI BioProject metadata; repeated submissions are grouped into one Atlas series.
Editorial note
Repository verification confirms the accession and regional connection, not whether the broader research programme remains active.
Sources
- primary record source Verified 2026-08-15
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