سجل مستودعي · ncbi-prjeb90586

Genomic Analysis of VRE from Hospitalized Patients in Saudi Arabia

Vancomycin-resistant Enterococcus (VRE) was first identified in Saudi Arabia in 1993, and numerous studies have since documented its prevalence across the Kingdom. However, a significant portion of this research has been limited by small sample sizes, often fewer than 50 isolates, and a lack of comprehensive molecular characterization. While a preliminary whole-genome sequencing (WGS) study of 29 isolates revealed novel findings, a larger-scale analysis is necessary to fully understand the evolution of VRE in this region. This study, therefore, aims to address this gap by determining the phenotypic and genotypic resistance profiles, virulence determinants, and sequence types of 75 VRE isolates collected from hospitalized patients in Riyadh, Saudi Arabia.